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IMM-H007
CAS No. 1221412-23-2
IMM-H007( —— )
Catalog No. M23389 CAS No. 1221412-23-2
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 170 | In Stock |
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| 10MG | 266 | In Stock |
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| 25MG | 533 | In Stock |
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| 50MG | 761 | In Stock |
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| 100MG | 1053 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIMM-H007
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NoteResearch use only, not for human use.
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Brief DescriptionIMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.
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DescriptionIMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.
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In Vitro——
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In VivoIMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids.IMM-H007 (200?mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1221412-23-2
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Formula Weight369.4
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Molecular FormulaC18H19N5O4
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCC(=O)OC[C@H]1CC[C@@H](O1)N2C=NC3=C(N=CN=C32)NC4=CC(=CC=C4)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jy C , MD Hong, Hyl F , et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling[J]. Toxicology and Applied Pharmacology, 2019, 381:114732-.
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