IMM-H007

CAS No. 1221412-23-2

IMM-H007( —— )

Catalog No. M23389 CAS No. 1221412-23-2

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 170 In Stock
10MG 266 In Stock
25MG 533 In Stock
50MG 761 In Stock
100MG 1053 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    IMM-H007
  • Note
    Research use only, not for human use.
  • Brief Description
    IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.
  • Description
    IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.
  • In Vitro
    ——
  • In Vivo
    IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids.IMM-H007 (200?mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1221412-23-2
  • Formula Weight
    369.4
  • Molecular Formula
    C18H19N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    CC(=O)OC[C@H]1CC[C@@H](O1)N2C=NC3=C(N=CN=C32)NC4=CC(=CC=C4)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jy C , MD Hong, Hyl F , et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling[J]. Toxicology and Applied Pharmacology, 2019, 381:114732-.
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