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IM-12
CAS No. 1129669-05-1
IM-12( IM 12 | IM12 )
Catalog No. M10456 CAS No. 1129669-05-1
IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
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| 10MG | 71 | In Stock |
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| 25MG | 141 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 444 | In Stock |
|
| 500MG | 981 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIM-12
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NoteResearch use only, not for human use.
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Brief DescriptionIM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
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DescriptionIM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling; attenuates cell proliferation of ReNcell VM cells, induces nuclear accumulation of beta-catenin.
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In VitroIM-12 inhibits GSK-3β in ReNcell VM cells, with I50 of 3.8 μM. IM-12 (3 μM) enhances the β-catenin amount, with no further effect at lower or higher concentration. IM-12 (3 μM) also attenuates the proliferation of ReNCell VM cells. IM-12 increases TCF-activity of ReNcell VM.
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In Vivo——
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SynonymsIM 12 | IM12
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3β
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1129669-05-1
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Formula Weight377.4115
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Molecular FormulaC22H20FN3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 54.9 mg/mL
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SMILESFC(C=C1)=CC=C1CCNC(C2=O)=C(C(N2C)=O)C(C3=C(C=CC=C3)N4)=C4C
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Chemical Name1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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9-ING-41
9-ING-41 is a glycogen synthase kinase-3 inhibitor.9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM.
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MeBIO
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
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A 1070722
A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM).
