Cart
sales@molnova.com
IM-12
CAS No. 1129669-05-1
IM-12( IM 12 | IM12 )
Catalog No. M10456 CAS No. 1129669-05-1
IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
|
| 10MG | 71 | In Stock |
|
| 25MG | 141 | In Stock |
|
| 50MG | 267 | In Stock |
|
| 100MG | 444 | In Stock |
|
| 500MG | 981 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIM-12
-
NoteResearch use only, not for human use.
-
Brief DescriptionIM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
-
DescriptionIM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling; attenuates cell proliferation of ReNcell VM cells, induces nuclear accumulation of beta-catenin.
-
In VitroIM-12 inhibits GSK-3β in ReNcell VM cells, with I50 of 3.8 μM. IM-12 (3 μM) enhances the β-catenin amount, with no further effect at lower or higher concentration. IM-12 (3 μM) also attenuates the proliferation of ReNCell VM cells. IM-12 increases TCF-activity of ReNcell VM.
-
In Vivo——
-
SynonymsIM 12 | IM12
-
PathwayPI3K/Akt/mTOR signaling
-
TargetGSK-3
-
RecptorGSK-3β
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number1129669-05-1
-
Formula Weight377.4115
-
Molecular FormulaC22H20FN3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 54.9 mg/mL
-
SMILESFC(C=C1)=CC=C1CCNC(C2=O)=C(C(N2C)=O)C(C3=C(C=CC=C3)N4)=C4C
-
Chemical Name1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Schm?le AC, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.
molnova catalog
related products
-
A 1070722
A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM).
-
MMBO
MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.
-
BRD3731
BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).
