IM-12

CAS No. 1129669-05-1

IM-12( IM 12 | IM12 )

Catalog No. M10456 CAS No. 1129669-05-1

IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 71 In Stock
25MG 141 In Stock
50MG 267 In Stock
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Biological Information

  • Product Name
    IM-12
  • Note
    Research use only, not for human use.
  • Brief Description
    IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling.
  • Description
    IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling; attenuates cell proliferation of ReNcell VM cells, induces nuclear accumulation of beta-catenin.
  • In Vitro
    IM-12 inhibits GSK-3β in ReNcell VM cells, with I50 of 3.8 μM. IM-12 (3 μM) enhances the β-catenin amount, with no further effect at lower or higher concentration. IM-12 (3 μM) also attenuates the proliferation of ReNCell VM cells. IM-12 increases TCF-activity of ReNcell VM.
  • In Vivo
    ——
  • Synonyms
    IM 12 | IM12
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3β
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    1129669-05-1
  • Formula Weight
    377.4115
  • Molecular Formula
    C22H20FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 54.9 mg/mL
  • SMILES
    FC(C=C1)=CC=C1CCNC(C2=O)=C(C(N2C)=O)C(C3=C(C=CC=C3)N4)=C4C
  • Chemical Name
    1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schm?le AC, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.
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