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IDE1

CAS No. 1160927-48-9

IDE1 ( IDE1; IDE-1; IDE 1 )

Catalog No. M17158 CAS No. 1160927-48-9

IDE1 can induce definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IDE1
  • Note
    Research use only, not for human use.
  • Brief Description
    IDE1 can induce definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells.
  • Description
    IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2 (ab145223). IDE1 induces Sox17 expression. It also activates TGF-β signaling and downstream Smad2 phosphorylation. IDE1 upregulates Nodal expression.
  • Synonyms
    IDE1; IDE-1; IDE 1
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1160927-48-9
  • Formula Weight
    306.3
  • Molecular Formula
    C15H18N2O5
  • Purity
    98%
  • Solubility
    DMSO : ≥ 30 mg/mL 97.94 mM
  • SMILES
    c1ccc(c(c1)/C=N/NC(=O)CCCCCC(=O)O)C(=O)O
  • Chemical Name
    7-[2-(2-Carboxybenzylidene)hydrazinyl]-7-oxoheptanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hoveizi E, et al. J Biomed Mater Res A. 2014 Nov;102(11):4027-36.
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