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ICCB280
CAS No. 2041072-41-5
ICCB280( —— )
Catalog No. M23912 CAS No. 2041072-41-5
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 97 | In Stock |
|
| 5MG | 160 | In Stock |
|
| 10MG | 290 | In Stock |
|
| 25MG | 470 | In Stock |
|
| 50MG | 683 | In Stock |
|
| 100MG | 954 | In Stock |
|
| 500MG | 1917 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameICCB280
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NoteResearch use only, not for human use.
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Brief DescriptionICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
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DescriptionICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
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In VitroICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM.ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells. Cell Viability Assay Cell Line:HL-60 cells Concentration:0.1, 0.5, 1, 5, 10, 50 μM Incubation Time:48 hours Result:Induced cell growth arrest, with an IC50 of 8.6 μM.Western Blot Analysis Cell Line:HL-60 cells Concentration:10 μM Incubation Time:2, 4, 6, 8 days Result:Upregulated the C/EBPα protein on day 4.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorC/EBPα
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Research Area——
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Indication——
Chemical Information
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CAS Number2041072-41-5
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Formula Weight386.4
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Molecular FormulaC23H18N2O4
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Purity>98% (HPLC)
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SolubilityDMSO:85mg/mL (219.98mM)
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SMILESO=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Radomska HS, Jernigan F, Nakayama S, et al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015;20(9):1150-1159. doi:10.1177/1087057115592220
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