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IACS-13909
CAS No. 2160546-07-4
IACS-13909( BBP-398 | IACS 13909 )
Catalog No. M23977 CAS No. 2160546-07-4
IACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 215 | In Stock |
|
| 10MG | 340 | In Stock |
|
| 25MG | 575 | In Stock |
|
| 50MG | 822 | In Stock |
|
| 100MG | 1107 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIACS-13909
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NoteResearch use only, not for human use.
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Brief DescriptionIACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
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DescriptionIACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
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In VitroCell Proliferation Assay Cell Line:Wild-type SHP2 and KYSE-520 cells Concentration:10 nM, 100 nM, 1 μM, 10 μM Incubation Time:14 days Result:Potently suppressed the cell proliferation. Western Blot Analysis Cell Line:Wild-type SHP2 and KYSE-520 cellsConcentration:1 μM, 5 μM Incubation Time:2 hours Result:Potently suppressed pERK and pMEK levels.
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In VivoAnimal Model:NSG mice (20-28 g) injected with KYSE-520 cells Dosage:70 mg/kg Administration:Oral administration; daily; for 21 days Result:Potently suppressed tumor growth in mice.
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SynonymsBBP-398 | IACS 13909
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorSHP-2
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Research Area——
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Indication——
Chemical Information
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CAS Number2160546-07-4
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Formula Weight377.27
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Molecular FormulaC17H18Cl2N6
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Purity>98% (HPLC)
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SolubilityDMSO:9 mg/mL?(23.86 mM;?Need ultrasonic)
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SMILESNC1(C)CCN(C2=CN=C3C(NN=C3C4=CC=CC(Cl)=C4Cl)=N2)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 Nov 1;80(21).4840-4853.
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