Hydroxyfasudil

CAS No. 105628-72-6

Hydroxyfasudil( HA-1100 | Hydroxy-Fasudil )

Catalog No. M23260 CAS No. 105628-72-6

Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 50 In Stock
5MG 73 In Stock
10MG 88 In Stock
25MG 203 In Stock
50MG 371 In Stock
100MG 552 In Stock
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Biological Information

  • Product Name
    Hydroxyfasudil
  • Note
    Research use only, not for human use.
  • Brief Description
    Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
  • Description
    Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
  • In Vitro
    Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC50 of 37 μM, 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC50 value of 0.8 ± 0.3 μM. Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μM.
  • In Vivo
    Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats.
  • Synonyms
    HA-1100 | Hydroxy-Fasudil
  • Pathway
    Apoptosis
  • Target
    PKA
  • Recptor
    PKA|ROCK|ROCK1|ROCK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    105628-72-6
  • Formula Weight
    307.37
  • Molecular Formula
    C14H17N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31 mg/mL (100.86 mM)
  • SMILES
    O=C1NC=CC2=C1C=CC=C2S(=O)(N3CCNCCC3)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ray P, Wright J, Adam J, Boucharens S, Black D, Brown AR, Epemolu O, Fletcher D, Huggett M, Jones P, Laats S, Lyons A, de Man J, Morphy R, Sherborne B, Sherry L, Straten Nv, Westwood P, York M. Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1084-8. doi: 10.1016/j.bmcl.2010.12.104. Epub 2010 Dec 28. PubMed PMID: 21251828.
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