
Hydroxyfasudil
CAS No. 105628-72-6
Hydroxyfasudil( HA-1100 | Hydroxy-Fasudil )
Catalog No. M23260 CAS No. 105628-72-6
Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 50 | In Stock |
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5MG | 73 | In Stock |
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10MG | 88 | In Stock |
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25MG | 203 | In Stock |
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50MG | 371 | In Stock |
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100MG | 552 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameHydroxyfasudil
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NoteResearch use only, not for human use.
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Brief DescriptionHydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
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DescriptionHydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
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In VitroHydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC50 of 37 μM, 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC50 value of 0.8 ± 0.3 μM. Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μM.
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In VivoHydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats.
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SynonymsHA-1100 | Hydroxy-Fasudil
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PathwayApoptosis
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TargetPKA
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RecptorPKA|ROCK|ROCK1|ROCK2
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Research Area——
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Indication——
Chemical Information
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CAS Number105628-72-6
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Formula Weight307.37
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Molecular FormulaC14H17N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO:31 mg/mL (100.86 mM)
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SMILESO=C1NC=CC2=C1C=CC=C2S(=O)(N3CCNCCC3)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference



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