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Hydroxybupropion

CAS No. 92264-81-8

Hydroxybupropion ( 6-Hydroxybupropion; Hydroxybupropion, (+/-)-; Hydroxybupropione )

Catalog No. M26253 CAS No. 92264-81-8

Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hydroxybupropion
  • Note
    Research use only, not for human use.
  • Brief Description
    Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent.
  • Description
    Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake (IC50: 1.7 μM). Hydroxybupropion is also a nACh receptor antagonist more potent than Bupropion.(In Vitro):Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents.
  • Synonyms
    6-Hydroxybupropion; Hydroxybupropion, (+/-)-; Hydroxybupropione
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PEGs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    92264-81-8
  • Formula Weight
    255.7
  • Molecular Formula
    C13H18ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(NC(C)(C)CO)C(=O)c1cccc(Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.
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