Hydroxybupropion

CAS No. 92264-81-8

Hydroxybupropion ( 6-Hydroxybupropion; Hydroxybupropion, (+/-)-; Hydroxybupropione )

Catalog No. M26253 CAS No. 92264-81-8

Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 158 Get Quote
5MG 267 Get Quote
10MG 417 Get Quote
25MG 669 Get Quote
50MG 888 Get Quote
100MG 1233 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Hydroxybupropion
  • Note
    Research use only, not for human use.
  • Brief Description
    Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent.
  • Description
    Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake (IC50: 1.7 μM). Hydroxybupropion is also a nACh receptor antagonist more potent than Bupropion.(In Vitro):Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents.
  • Synonyms
    6-Hydroxybupropion; Hydroxybupropion, (+/-)-; Hydroxybupropione
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PEGs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    92264-81-8
  • Formula Weight
    255.7
  • Molecular Formula
    C13H18ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(NC(C)(C)CO)C(=O)c1cccc(Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.
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