
Hydrocoumarin
CAS No. 119-84-6
Hydrocoumarin( Hydrocoumarin | Chroman-2-one )
Catalog No. M17874 CAS No. 119-84-6
Spice, used in food, also used as a substitute for coumarin; used in cosmetics.
Purity : >98% (HPLC)






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25MG | 49 | In Stock |
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Biological Information
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Product NameHydrocoumarin
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NoteResearch use only, not for human use.
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Brief DescriptionSpice, used in food, also used as a substitute for coumarin; used in cosmetics.
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DescriptionSpice, used in food, also used as a substitute for coumarin; used in cosmetics.
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In VitroDihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC50 of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM).Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line.Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period.
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In Vivo——
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SynonymsHydrocoumarin | Chroman-2-one
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number119-84-6
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Formula Weight148.16
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Molecular FormulaC9H8O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (674.95 mM)
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SMILESC1CC(=O)OC2=CC=CC=C21
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog



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