Hydrocortisone

Research use only, not for human use.

Hydrocortisone is a main?glucocorticoid?secreted by the adrenal cortex.

Hydrocortisone is a main?glucocorticoid?secreted by the adrenal cortex.(In Vitro):Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells.

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Cortisol | Dihydrocostisone | NSC 10483

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Inflammation/Immunology

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50-23-7

362.46

C21H30O5

>98% (HPLC)

Ethanol: 23 mg/mL (63.45 mM); DMSO: 73 mg/mL (201.4 mM)

C[C@@]12[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

(-20℃)

With Ice Pack

≥ 2 years