Homobutein

CAS No. 34000-39-0

Homobutein( 2',4,4'-Trihydroxy-3-methoxychalcone | 3-O-Methylbutein )

Catalog No. M29306 CAS No. 34000-39-0

Homobutein is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 264 In Stock
5MG 402 In Stock
10MG 593 In Stock
25MG 888 In Stock
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Biological Information

  • Product Name
    Homobutein
  • Note
    Research use only, not for human use.
  • Brief Description
    Homobutein is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.
  • Description
    Homobutein is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.(In Vitro):Homobutein (1 μg/mL) inhibits the growth of Toxoplasma gondii by 19.48% with IC50s of 15.0 and 16.1 μM for W2 and D6 strains of P. falciparum. Homobutein (20 - 40 μM) inhibits the viability and TNFα-induced NF-κB activity of K562 cells.
  • In Vitro
    Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells.Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells.Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%.Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 μM, respectively.Cell Viability Assay Cell Line:K562 cells Concentration:20, 24, 28, 32, 40 μM Incubation Time:2 h Result:Showed inhibition of viability in K562 cells.Cell Viability AssayCell Line:Toxoplasma gondii RH-2F strain Concentration:1 μg/mL Incubation Time:72 h Result:Surpressed 19.48% of the Toxoplasma gondii.
  • In Vivo
    ——
  • Synonyms
    2',4,4'-Trihydroxy-3-methoxychalcone | 3-O-Methylbutein
  • Pathway
    Others
  • Target
    Antioxidant
  • Recptor
    Antioxidant
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    34000-39-0
  • Formula Weight
    286.28
  • Molecular Formula
    C16H14O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(=C/C(=O)C1=C(O)C=C(O)C=C1)\C2=CC(OC)=C(O)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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