Histrelin

Research use only, not for human use.

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency.

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of the prostate in men and uterine fibroids in women.

Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants.Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.

Animal Model:Csfmop/Csfmop mice Dosage:0.001, 0.05, and 0.1 mg/kg Administration:Subcutaneous injection Result:Increased serum FSH concentrations by 4-fold.Animal Model:Rabbits Dosage:10, 30, or 100 μg /day Administration:Subcutaneous injection for 4 weeks Result:Caused a regression of the endometrial glands and a thinning of the stroma.

Supprelin LA

Others

Other Targets

Others

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76712-82-8

1323.5

C66H86N18O12

>98% (HPLC)

DMSO:Soluble; Water:Insoluble

CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

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(-20℃)

With Ice Pack

≥ 2 years