
Hispidol
CAS No. 5786-54-9
Hispidol( (Z)-Hispidol )
Catalog No. M17546 CAS No. 5786-54-9
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
Purity : >98% (HPLC)






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Biological Information
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Product NameHispidol
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NoteResearch use only, not for human use.
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Brief DescriptionHispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
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DescriptionHispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
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In VitroHispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression.
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In VivoThe oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.
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Synonyms(Z)-Hispidol
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorTNF-α
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Research Area——
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Indication——
Chemical Information
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CAS Number5786-54-9
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Formula Weight254.24
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Molecular FormulaC15H10O4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 393.33 mM
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SMILESc1cc(ccc1/C=C\1/C(=O)c2c(O1)cc(cc2)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kadayat TM, et al. Eur J Med Chem. 2017 Sep 8;137:575-597.
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