Hispidol

CAS No. 5786-54-9

Hispidol( (Z)-Hispidol )

Catalog No. M17546 CAS No. 5786-54-9

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 80 In Stock
10MG 132 In Stock
25MG 201 In Stock
50MG 260 In Stock
100MG 410 In Stock
200MG 560 In Stock
500MG 954 In Stock
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Biological Information

  • Product Name
    Hispidol
  • Note
    Research use only, not for human use.
  • Brief Description
    Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
  • Description
    Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.
  • In Vitro
    Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression.
  • In Vivo
    The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.
  • Synonyms
    (Z)-Hispidol
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    TNF-α
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    5786-54-9
  • Formula Weight
    254.24
  • Molecular Formula
    C15H10O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL; 393.33 mM
  • SMILES
    c1cc(ccc1/C=C\1/C(=O)c2c(O1)cc(cc2)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kadayat TM, et al. Eur J Med Chem. 2017 Sep 8;137:575-597.
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