Hinokitiol

CAS No. 499-44-5

Hinokitiol( 4-Isopropyltropolone | β-Thujaplicin )

Catalog No. M14672 CAS No. 499-44-5

Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 27 In Stock
50MG 38 In Stock
100MG 67 In Stock
200MG 87 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Hinokitiol
  • Note
    Research use only, not for human use.
  • Brief Description
    Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest.
  • Description
    Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest, exhibits anti-inflammatory and anti-tumor activities; inhibits the proliferation of Chlamydia trachomatis with MIC of 32 ug/mL; also can harness such gradients to restore iron transport into, within, and/or out of cells.
  • In Vitro
    In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC50 values of 316.5 ± 35.5 and 152.5 ± 25.3 μM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT, CHST10, and BTG4 genes.
  • In Vivo
    ——
  • Synonyms
    4-Isopropyltropolone | β-Thujaplicin
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    ERα
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    499-44-5
  • Formula Weight
    164.204
  • Molecular Formula
    C10H12O2
  • Purity
    >98% (HPLC)
  • Solubility
    Chloroform: Soluble DMSO: 29 mg/mL (176.6 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    CC(C)C1=CC(=O)C(=CC=C1)O
  • Chemical Name
    2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yamano H, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2519-21. 2. Seo JS, et al. BMC Cell Biol. 2017 Feb 27;18(1):14. 3. Grillo AS, et al. Science. 2017 May 12;356(6338):608-616.
molnova catalog
related products
  • Triglycidyl isocyanu...

    Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research.

  • Cholesteryl Hemisucc...

    Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties.

  • PHYTOSPHINGOSINE

    Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.