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HexylHIBO

CAS No. 334887-43-3

HexylHIBO( —— )

Catalog No. M33866 CAS No. 334887-43-3

HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HexylHIBO
  • Note
    Research use only, not for human use.
  • Brief Description
    HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.
  • Description
    HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat.
  • In Vitro
    Thus ambient levels of glutamate tonically activate mGluRs and regulate cortical excitability.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    334887-43-3
  • Formula Weight
    256.3
  • Molecular Formula
    C12H20N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(CCCCC)C1=C(CC(C(O)=O)N)ONC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44(7):1051-1059.?
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