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Hexa-D-arginine

CAS No. 673202-67-0

Hexa-D-arginine( —— )

Catalog No. M21017 CAS No. 673202-67-0

Hexa-D-arginine?is an inhibitor of furinblocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hexa-D-arginine
  • Note
    Research use only, not for human use.
  • Brief Description
    Hexa-D-arginine?is an inhibitor of furinblocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.
  • Description
    Hexa-D-arginine?is an inhibitor of furinblocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.
  • In Vitro
    Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
  • In Vivo
    Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    furin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    673202-67-0
  • Formula Weight
    954.14
  • Molecular Formula
    C36H75N25O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (52.40 mM)
  • SMILES
    C(C[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N)N)CN=C(N)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sarac M S Cameron A Lindberg I . The Furin Inhibitor Hexa-D-Arginine Blocks the Activation of Pseudomonas aeruginosa Exotoxin A In Vivo[J]. Infection and Immunity 2002 70(12):7136-7139.
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