Helenalin

Research use only, not for human use.

Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.

Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway; ablates p65 DNA-binding ability, exhibits low micromolar inhibition of induced NF-κB signaling (53.7±14.1% NF-κB activity at 2.5 uM); suppresses cell proliferation and promotes apoptosis in cultured fibroblasts.

Western Blot Analysis Cell Line:Jurkat T cells Concentration:10 μM Incubation Time:20-120 minutes Result:Caused complete inhibition of NF-κB DNA binding after 80 minutes.

Animal Model:Immature male ICR mice Dosage:25 mg/kg Administration:i.p.; 6 to 12 hours Result:Caused a rapid decrease in hepatic glutathione levels.

NSC 85236

Apoptosis

NF-κB

NF-κB

——

——

6754-13-8

262.305

C15H18O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (381.24 mM)

C[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2

3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione

(-20℃)

With Ice Pack

≥ 2 years