
Helenalin
CAS No. 6754-13-8
Helenalin( NSC 85236 )
Catalog No. M15580 CAS No. 6754-13-8
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.
Purity : >98% (HPLC)






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Biological Information
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Product NameHelenalin
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NoteResearch use only, not for human use.
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Brief DescriptionHelenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.
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DescriptionHelenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway; ablates p65 DNA-binding ability, exhibits low micromolar inhibition of induced NF-κB signaling (53.7±14.1% NF-κB activity at 2.5 uM); suppresses cell proliferation and promotes apoptosis in cultured fibroblasts.
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In VitroWestern Blot Analysis Cell Line:Jurkat T cells Concentration:10 μM Incubation Time:20-120 minutes Result:Caused complete inhibition of NF-κB DNA binding after 80 minutes.
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In VivoAnimal Model:Immature male ICR mice Dosage:25 mg/kg Administration:i.p.; 6 to 12 hours Result:Caused a rapid decrease in hepatic glutathione levels.
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SynonymsNSC 85236
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number6754-13-8
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Formula Weight262.305
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Molecular FormulaC15H18O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (381.24 mM)
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SMILESC[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2
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Chemical Name3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Widen JC, et al. ACS Chem Biol. 2017 Jan 20;12(1):102-113.
2. Chen S, et al. Cell Death Dis. 2017 Mar 30;8(3):e2710.
3. Lim CB, et al. BMC Complement Altern Med. 2012 Jul 11;12:93.
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