
Handelin
CAS No. 62687-22-3
Handelin( —— )
Catalog No. M24627 CAS No. 62687-22-3
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
Purity : >98% (HPLC)






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Biological Information
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Product NameHandelin
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NoteResearch use only, not for human use.
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Brief DescriptionHandelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
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DescriptionHandelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
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In VitroHandelin (Compound 1; 10-40 μM; RAW 264.7 cells) treatment suppresses the LPS-induced (1 μg/mL) overexpression of iNOS and COX-2 protein levels in a concentration-dependent manner. Handelin also suppresseS the induction of pro-inflammatory cytokines TNF-α and IL-1β in LPS-stimulated RAW 264.7 cells. Handelin also suppresses the activation of mitogen-activated protein kinases, including ERK and JNK signaling.Handelin (Compound 1; 10-40 μM; RAW 264.7 cells) treatment significantly reduces the iNOS and COX-2 mRNA levels in LPS- stimulated RAW 264.7 cells. The transcriptional activity of NF-κB stimulated with LPS is also suppressed by Handelin. In addition, the LPS-stimulated upregulation of miRNA-155 expression is suppressed by Handelin.RT-PCR Cell Line:RAW 264.7 cells Concentration:10 μM, 20 μM, 40 μM Incubation Time:5 hours Result:iNOS and COX-2 mRNA levels were significantly reduced. The transcriptional activity of NF-κB stimulated with LPS was also suppressed and the LPS-stimulated upregulation of miRNA-155 expression was also suppressed. Western Blot Analysis Cell Line:RAW 264.7 cells Concentration:10 μM, 20 μM, 40 μM Incubation Time:Result:Suppressed the LPS-induced overexpression of iNOS and COX-2 protein levels in a concentration-dependent manner. Suppressed the induction of pro-inflammatory cytokines TNF-α and IL-1β, and also also suppressed the activation of mitogen-activated protein kinases, including ERK and JNK signaling in LPS-stimulated RAW 264.7 cells.
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In VivoHandelin (Compound 1; 10-20 mg/kg; oral administration; for 30 mintues; male Sprague-Dawley rats) treatment inhibits acute inflammation in carrageenan-induced paw edema model. The serum level of IL-1β is also inhibited by Handelin in a carrageenan-induced paw edema model . Animal Model:Male Sprague-Dawley (SD) rats (150-170 g, 5 weeks old) injected with carrageenan Dosage:10 mg/kg, 20 mg/kg Administration:Oral administration; for 30 mintues Result:Inhibited acute inflammation in carrageenan-induced paw. The serum level of IL-1β was also inhibited.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorinflammation|NF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number62687-22-3
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Formula Weight552.66
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Molecular FormulaC32H40O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16.67 mg/mL (30.16 mM)
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SMILESC[C@]([C@]([C@@](OC1=O)([H])[C@@](C1=C)([H])CC[C@]2(O)C)([H])[C@@]32C4)(C=C3)[C@]54[C@@]([C@H]6OC(C)=O)([H])[C@]([C@](C(C)=CC7)([H])[C@]7([H])[C@](C)(O)C6)([H])OC5=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Request full-text Anti-inflammatory activity of handelin through the modulation of NF-κB signaling and pro-inflammatory cytokine productionsPlanta Med 2012; 78 - PD86.
molnova catalog



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