HSD-016( HSD016 | HSD 016 )

Catalog No. M16784 CAS No. 946396-92-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

HSD-016
Note

Research use only, not for human use.
Brief Description

HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.
Description

HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively; significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes with IC50 of 362 nM; HSD-016 (HSD016) has entered phase I clinical trials for the treatment of diabetes.Diabetes Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

HSD016 | HSD 016
Pathway

Metabolic Enzyme/Protease
Target

11β-HSD
Recptor

11β-HSD
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

946396-92-5
Formula Weight

514.459
Molecular Formula

C21H21F7N2O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (194.38 mM)
SMILES

CC1CN(CCN1S(=O)(=O)C2=CC=CC(=C2)C(C)(C(F)(F)F)O)C3=C(C=C(C=C3)F)C(F)(F)F
Chemical Name

(R)-1,1,1-trifluoro-2-(3-((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)propan-2-ol

1. Wan ZK, et al. J Org Chem. 2011 Sep 2;76(17):7048-55. 2. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999(18)30450-3.

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