HS271

CAS No. 2410393-15-4

HS271 ( —— )

Catalog No. M28114 CAS No. 2410393-15-4

HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 260 Get Quote
10MG 430 Get Quote
25MG 710 Get Quote
50MG 972 Get Quote
100MG 1332 Get Quote
500MG 2673 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    HS271
  • Note
    Research use only, not for human use.
  • Brief Description
    HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
  • Description
    HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.(In Vivo):In rat models of LPS-induced TNFα production collagen-induced arthritis, HS271 (15-150 mg/kg) shows robust antiinflammatory efficacy with a t1/2 of 3.3 h and Cmax of 2107 ng/mL. The oral bioavailability of HS271 is 67.3%, 58.2%, 14.4&% and 49% in mice, rats, dogs, and monkeys, respectively.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    G2019S LRRK2;LRRK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2410393-15-4
  • Formula Weight
    435.4
  • Molecular Formula
    C21H24F3N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N/A
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.
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