HS271
CAS No. 2410393-15-4
HS271 ( —— )
Catalog No. M28114 CAS No. 2410393-15-4
HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 260 | Get Quote |
|
10MG | 430 | Get Quote |
|
25MG | 710 | Get Quote |
|
50MG | 972 | Get Quote |
|
100MG | 1332 | Get Quote |
|
500MG | 2673 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameHS271
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NoteResearch use only, not for human use.
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Brief DescriptionHS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.
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DescriptionHS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.(In Vivo):In rat models of LPS-induced TNFα production collagen-induced arthritis, HS271 (15-150 mg/kg) shows robust antiinflammatory efficacy with a t1/2 of 3.3 h and Cmax of 2107 ng/mL. The oral bioavailability of HS271 is 67.3%, 58.2%, 14.4&% and 49% in mice, rats, dogs, and monkeys, respectively.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorG2019S LRRK2;LRRK2
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Research Area——
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Indication——
Chemical Information
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CAS Number2410393-15-4
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Formula Weight435.4
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Molecular FormulaC21H24F3N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN/A
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.
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