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HODHBt
CAS No. 28230-32-2
HODHBt( —— )
Catalog No. M22874 CAS No. 28230-32-2
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 35 | In Stock |
|
| 200MG | 50 | In Stock |
|
| 500MG | 82 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHODHBt
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NoteResearch use only, not for human use.
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Brief DescriptionHODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
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DescriptionHODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
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In VitroHODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells.HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells).HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10).HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro.
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In Vivo——
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Synonyms——
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT5
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Research Area——
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Indication——
Chemical Information
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CAS Number28230-32-2
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Formula Weight163.14
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Molecular FormulaC7H5N3O2
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESC1=CC=C2C(=C1)C(=O)N(N=N2)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bosque et al (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 18 1324 PMID: 28147284
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