HO-3867

Research use only, not for human use.

A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.

A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs; induces G2-M cell cycle arrest in A2780 cells by modulating cell cycle regulatory molecules p53, p21, p27, CDK 2, and cyclin, and promotes apoptosis, inhibits pSTAT3 (Tyr705 and Ser727) and JAK1 and increases apoptotic markers cleaved caspase-3 and PARP in xenograft tumor tissues.

HO 3867;HO3867

JAK/STAT Signaling

STAT

STAT3

Cancer

——

1172133-28-6

464.55

C28H30F2N2O2

>98% (HPLC)

DMSO: ≥ 32 mg/mL

O=C1/C(CN(CC2=CC(C)(C)N(O)C2(C)C)C/C1=C\C3=CC=C(F)C=C3)=C/C4=CC=C(F)C=C4

4-Piperidinone, 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-, (3E,5E)-

(-20℃)

With Ice Pack

≥ 2 years