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HJC0350

CAS No. 885434-70-8

HJC0350( HJC 0350 | HJC0350 | HJC-0350 )

Catalog No. M19231 CAS No. 885434-70-8

HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HJC0350
  • Note
    Research use only, not for human use.
  • Brief Description
    HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
  • Description
    HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). HJC 0350 displays no effect on Epac1. HJC 0350 blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
  • In Vitro
    HJC0350 has an apparent IC50 value of 0.3 μM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 μM HJC0350 fully blocks the 007-AM induced decrease of FRET.
  • In Vivo
    ——
  • Synonyms
    HJC 0350 | HJC0350 | HJC-0350
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    EPAC2
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    885434-70-8
  • Formula Weight
    277.38
  • Molecular Formula
    C15H19NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 33.33 mg/mL 120.16 mM
  • SMILES
    Cc1cc(c(c(c1)C)S(=O)(=O)n1cc(cc1C)C)C
  • Chemical Name
    2,4-dimethyl-1-(2,4,6-trimethylphenyl)sulfonylpyrrole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen H, et al. J Med Chem. 2013, 56(3), 952-962.
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