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HJC0350
CAS No. 885434-70-8
HJC0350( HJC 0350 | HJC0350 | HJC-0350 )
Catalog No. M19231 CAS No. 885434-70-8
HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 58 | In Stock |
|
| 25MG | 125 | In Stock |
|
| 50MG | 205 | In Stock |
|
| 100MG | 354 | In Stock |
|
| 200MG | 527 | In Stock |
|
| 500MG | 843 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHJC0350
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NoteResearch use only, not for human use.
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Brief DescriptionHJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
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DescriptionHJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). HJC 0350 displays no effect on Epac1. HJC 0350 blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
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In VitroHJC0350 has an apparent IC50 value of 0.3 μM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 μM HJC0350 fully blocks the 007-AM induced decrease of FRET.
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In Vivo——
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SynonymsHJC 0350 | HJC0350 | HJC-0350
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PathwayApoptosis
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TargetNF-κB
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RecptorEPAC2
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number885434-70-8
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Formula Weight277.38
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Molecular FormulaC15H19NO2S
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Purity>98% (HPLC)
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SolubilityDMSO : 33.33 mg/mL 120.16 mM
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SMILESCc1cc(c(c(c1)C)S(=O)(=O)n1cc(cc1C)C)C
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Chemical Name2,4-dimethyl-1-(2,4,6-trimethylphenyl)sulfonylpyrrole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen H, et al. J Med Chem. 2013, 56(3), 952-962.
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