HJC0197

CAS No. 1383539-73-8

HJC0197 ( —— )

Catalog No. M22183 CAS No. 1383539-73-8

HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 77 In Stock
10MG 117 In Stock
25MG 205 In Stock
50MG 332 In Stock
100MG 494 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    HJC0197
  • Note
    Research use only, not for human use.
  • Brief Description
    HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).
  • Description
    HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2). In the presence of an equal concentration of cAMP, HJC0197 (25 μM) also inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Epac1;Epac2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1383539-73-8
  • Formula Weight
    339.45
  • Molecular Formula
    C19H21N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1ccc(C)c(CSc2nc(C3CCCC3)c(C#N)c(=O)[nH]2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.
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