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HC-030031

CAS No. 349085-38-7

HC-030031( HC-030031 | HC 030031 | HC030031 )

Catalog No. M18464 CAS No. 349085-38-7

HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HC-030031
  • Note
    Research use only, not for human use.
  • Brief Description
    HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
  • Description
    HC-030031 is a potent and selective TRPA1 antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. HC-030031 antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HC-030031 | HC 030031 | HC030031
  • Pathway
    NF-κB
  • Target
    Free radical scavengers
  • Recptor
    TRPA1
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    349085-38-7
  • Formula Weight
    355.39
  • Molecular Formula
    C18H21N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 25 mg/mL 70.35 mM;
  • SMILES
    CC(C)c1ccc(NC(=O)Cn2cnc3c2c(=O)n(C)c(=O)n3C)cc1
  • Chemical Name
    2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. McNamara CR, et al. Proc Natl Acad Sci, 2007, 104(33), 13525-13530.
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