HAMNO

CAS No. 138736-73-9

HAMNO( HAMNO | CID 6335338, MLS000737724, NSC111847 )

Catalog No. M17989 CAS No. 138736-73-9

HAMNO is a protein interaction inhibitor of replication protein A (RPA).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 42 In Stock
10MG 72 In Stock
25MG 147 In Stock
50MG 267 In Stock
100MG 483 In Stock
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Biological Information

  • Product Name
    HAMNO
  • Note
    Research use only, not for human use.
  • Brief Description
    HAMNO is a protein interaction inhibitor of replication protein A (RPA).
  • Description
    HAMNO, also known as NSC-111847, is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response.
  • In Vitro
    HAMNO is a novel protein interaction inhibitor of replication protein A (RPA).RPA is involved in the ATR/Chk1 pathway.HAMNO alone inhibits colony formation in both HNSCC cell lines in the low micromolar range. HAMNO combined with etoposide significantly inhibits colony formation to a greater degree than HAMNO alone. After UMSCC38 cells are exposed to HAMNO, increased pan-nuclear γ-H2AX staining occurs in a dose dependent manner. Cancer derived UMSCC38 cells, as well as another cancer cell line, UMSCC11B, have prominent γ-H2AX staining, particularly after incubation with 20 μM HAMNO. Both UMSCC38 and OKF4 cells present increased γ-H2AX staining after addition of HAMNO, with the greatest increase in signal occurring in S-phase.
  • In Vivo
    In mice, HAMNO slows the progression of UMSCC11B tumors. Ser33 of RPA32, an ATR substrate, is highly phosphorylated after two hours of treatment with 20 μM of etoposide, which is reduced with the addition of 2 μM HAMNO, and is nearly absent at higher concentrations, demonstrating an in vivo effect of HAMNO as an inhibitor of RPA32 phosphorylation by ATR.
  • Synonyms
    HAMNO | CID 6335338, MLS000737724, NSC111847
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    LIM Kinase (LIMK)
  • Recptor
    DNA replication
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    138736-73-9
  • Formula Weight
    263.3
  • Molecular Formula
    C17H13NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 155 mg/mL 588.70 mM;
  • SMILES
    Oc1ccccc1N\C=C1/C(=O)C=Cc2ccccc12
  • Chemical Name
    (1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Glanzer JG, et al. RPA inhibition increases replication stress and suppresses tumor growth. Cancer Res. 2014 Sep 15;74(18):5165-72.
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