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H3B-8800
CAS No. 1825302-42-8
H3B-8800( H3B8800 )
Catalog No. M12816 CAS No. 1825302-42-8
H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 348 | In Stock |
|
| 5MG | 698 | In Stock |
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| 25MG | 1780 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameH3B-8800
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NoteResearch use only, not for human use.
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Brief DescriptionH3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex.
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DescriptionH3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2 nM); demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells.Blood Cancer Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsH3B8800
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PathwayOthers
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TargetSpliceosome
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RecptorSpliceosome
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1825302-42-8
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Formula Weight555.716
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Molecular FormulaC31H45N3O6
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N1CCN(C)CC1)O[C@H]([C@](C)(O)CC[C@@H](O)C2)/C=C/[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C3=NC=CC=C3)C)OC2=O
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Chemical Name(2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Seiler M, et al. Nat Med. 2018 Feb 19. doi: 10.1038/nm.4493.
2. Finci LI, et al. Genes Dev. 2018 Feb 1;32(3-4):309-320.
3. Cancer Discov. 2018 Mar 2. doi: 10.1158/2159-8290.CD-RW2018-038.
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