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H3B-120

CAS No. 2194903-42-7

H3B-120 ( —— )

Catalog No. M26243 CAS No. 2194903-42-7

H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 222 Get Quote
10MG 372 Get Quote
25MG 623 Get Quote
50MG 887 Get Quote
100MG 1197 Get Quote
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Biological Information

  • Product Name
    H3B-120
  • Note
    Research use only, not for human use.
  • Brief Description
    H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
  • Description
    H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.(In Vitro):H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.?The half-life of H3B-120 is only 40 min.?H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Akt; p38 MAPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2194903-42-7
  • Formula Weight
    372.5
  • Molecular Formula
    C19H24N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN(Cc1ccccc1)C(=O)N1CCC(CC1)C(=O)Nc1nc(C)cs1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.?Bai ZT,?et al. Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK and EMT related signals in hepatocellular carcinoma cells. Bioorg Med Chem Lett.?2017 Feb 15;27(4):989-993.
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