H3B-120
CAS No. 2194903-42-7
H3B-120 ( —— )
Catalog No. M26243 CAS No. 2194903-42-7
H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 222 | Get Quote |
|
10MG | 372 | Get Quote |
|
25MG | 623 | Get Quote |
|
50MG | 887 | Get Quote |
|
100MG | 1197 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameH3B-120
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NoteResearch use only, not for human use.
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Brief DescriptionH3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
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DescriptionH3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.(In Vitro):H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.?The half-life of H3B-120 is only 40 min.?H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAkt; p38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number2194903-42-7
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Formula Weight372.5
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Molecular FormulaC19H24N4O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESCN(Cc1ccccc1)C(=O)N1CCC(CC1)C(=O)Nc1nc(C)cs1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.?Bai ZT,?et al. Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK and EMT related signals in hepatocellular carcinoma cells. Bioorg Med Chem Lett.?2017 Feb 15;27(4):989-993.
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