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H-Ile-Pro-Pro-OH

CAS No. 26001-32-1

H-Ile-Pro-Pro-OH( —— )

Catalog No. M30448 CAS No. 26001-32-1

H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    H-Ile-Pro-Pro-OH
  • Note
    Research use only, not for human use.
  • Brief Description
    H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM.
  • Description
    H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. (In Vitro):Vitro: Ile-Pro-Pro (IPP) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs).(In Vivo):Vivo: Ile-Pro-Pro attenuates arterial dysfunction in L-NAME-treated rats Ile-Pro-Pro (IPP) decreases blood pressure in spontaneously hypertensive rats (SHR) . Ile-Pro-Pro (IPP) attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice.
  • In Vitro
    Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs).
  • In Vivo
    Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats.Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) .Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient(apoE(-/-)) mice.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    ACE
  • Recptor
    IC50: 5 μM (ACE)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    26001-32-1
  • Formula Weight
    325.4
  • Molecular Formula
    C16H27N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7.
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