H-151

Research use only, not for human use.

H-151 is a highly potent selective and covalent antagonist of?STING reduces TBK1 phosphorylation and suppresses human STING palmitoylation.

H-151 is a highly potent selective and covalent antagonist of?STING reduces TBK1 phosphorylation and suppresses human STING palmitoylation.(In Vitro):H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.(In Vivo):H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1?/? mice that expressed a bioluminescent IFNβ reporter.H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.

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Immunology/Inflammation

STING

STING

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941987-60-6

279.34

C17H17N3O?

>98% (HPLC)

DMSO:125 mg/mL (447.48 mM; Need ultrasonic)

CCc1ccc(NC(=O)Nc2c[nH]c3ccccc23)cc1

N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea

(-20℃)

With Ice Pack

≥ 2 years