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Golcadomide

CAS No. 2379572-34-4

Golcadomide( —— )

Catalog No. M35741 CAS No. 2379572-34-4

Golcadomide (CC-99282) is a orally active CRBN E3 ligase modulator that induces interactions between CRBN and its neo-substrate, recruiting the target disease-causing proteins and the E3 ubiquitin ligase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Golcadomide
  • Note
    Research use only, not for human use.
  • Brief Description
    Golcadomide (CC-99282) is a orally active CRBN E3 ligase modulator that induces interactions between CRBN and its neo-substrate, recruiting the target disease-causing proteins and the E3 ubiquitin ligase.
  • Description
    Golcadomide (CC-99282) is a potent and orally active cereblon (CRBN) E3 ligase modulator (CELMoD). Golcadomide co-opts CRBN to induce potent and targeted degradation of Ikaros and Aiolos. Golcadomide can be used for researching non-Hodgkin lymphomas.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    E3 Ligase Ligand
  • Recptor
    Ligand for E3 Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2379572-34-4
  • Formula Weight
    535.57
  • Molecular Formula
    C28H30FN5O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (233.40 mM; Ultrasonic )
  • SMILES
    N(CC1=C(F)C=C(CN2CC(C2)N3CCOCC3)C=C1)C4=C5C(C(=O)N(C5=O)[C@@H]6C(=O)NC(=O)CC6)=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. J.-M. Michot, et al. A PHASE 1, MULTICENTER, OPEN-LABEL STUDY OF CC-99282 ALONE AND IN COMBINATION WITH RITUXIMAB IN PATIENTS WITH RELAPSED OR REFRACTORY NON-HODGKIN LYMPHOMAS. Hematological Oncology. Volume 39, Issue S2, Jun. 2021.
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