
Golcadomide
CAS No. 2379572-34-4
Golcadomide( —— )
Catalog No. M35741 CAS No. 2379572-34-4
Golcadomide (CC-99282) is a orally active CRBN E3 ligase modulator that induces interactions between CRBN and its neo-substrate, recruiting the target disease-causing proteins and the E3 ubiquitin ligase.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 251 | Get Quote |
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5MG | 392 | Get Quote |
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10MG | 629 | Get Quote |
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25MG | 1214 | Get Quote |
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50MG | 1950 | Get Quote |
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100MG | 3042 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameGolcadomide
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NoteResearch use only, not for human use.
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Brief DescriptionGolcadomide (CC-99282) is a orally active CRBN E3 ligase modulator that induces interactions between CRBN and its neo-substrate, recruiting the target disease-causing proteins and the E3 ubiquitin ligase.
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DescriptionGolcadomide (CC-99282) is a potent and orally active cereblon (CRBN) E3 ligase modulator (CELMoD). Golcadomide co-opts CRBN to induce potent and targeted degradation of Ikaros and Aiolos. Golcadomide can be used for researching non-Hodgkin lymphomas.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetE3 Ligase Ligand
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RecptorLigand for E3 Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number2379572-34-4
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Formula Weight535.57
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Molecular FormulaC28H30FN5O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (233.40 mM; Ultrasonic )
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SMILESN(CC1=C(F)C=C(CN2CC(C2)N3CCOCC3)C=C1)C4=C5C(C(=O)N(C5=O)[C@@H]6C(=O)NC(=O)CC6)=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. J.-M. Michot, et al. A PHASE 1, MULTICENTER, OPEN-LABEL STUDY OF CC-99282 ALONE AND IN COMBINATION WITH RITUXIMAB IN PATIENTS WITH RELAPSED OR REFRACTORY NON-HODGKIN LYMPHOMAS. Hematological Oncology. Volume 39, Issue S2, Jun. 2021.
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