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Glycerophosphocholine

CAS No. 28319-77-9

Glycerophosphocholine ( Choline Alfoscerate; Alpha GPC; Choline glycerophosphate )

Catalog No. M18359 CAS No. 28319-77-9

Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Glycerophosphocholine
  • Note
    Research use only, not for human use.
  • Brief Description
    Glycerylphosphorylcholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia.
  • Description
    Choline Alfoscerate, also known as Alpha GPC and L-Alpha glycerylphosphorylcholine, is a component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. Choline Alfoscerate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. Choline Alfoscerate is used in the treatment of Alzheimer's Disease and other dementias.
  • Synonyms
    Choline Alfoscerate; Alpha GPC; Choline glycerophosphate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AChE
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    28319-77-9
  • Formula Weight
    257.22
  • Molecular Formula
    C8H20NO6P
  • Purity
    98%
  • Solubility
    H2O : 500 mg/mL 1943.86 mM; DMSO : ≥ 125 mg/mL 485.97 mM
  • SMILES
    C[N+](C)(C)CCOP(=O)([O-])OC[C@@H](CO)O
  • Chemical Name
    (R)-2,3-dihydroxypropyl (2-(trimethylammonio)ethyl) phosphate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9.
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