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Gly-Gly-Gly-PEG4-DBCO
Gly-Gly-Gly-PEG4-DBCO
CAS No. 2353409-80-8
Gly-Gly-Gly-PEG4-DBCO( —— )
Catalog No. M33551 CAS No. 2353409-80-8
Gly-Gly-Gly-PEG4-DBCO is a degradable ADC linker containing 4 units of PEG, which can be used to synthesize antibody-conjugated active molecules (ADCs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 128 | In Stock |
|
| 5MG | 188 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGly-Gly-Gly-PEG4-DBCO
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NoteResearch use only, not for human use.
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Brief DescriptionGly-Gly-Gly-PEG4-DBCO is a degradable ADC linker containing 4 units of PEG, which can be used to synthesize antibody-conjugated active molecules (ADCs).
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DescriptionGly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In Vivo——
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Synonyms——
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PathwayAntibody Drug Conjugates (ADC)
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TargetADCs Linker/Click Chemistry
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RecptorADC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number2353409-80-8
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Formula Weight694.77
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Molecular FormulaC35H46N6O9
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (143.93 mM; Ultrasonic )Methanol : 50 mg/mL (71.97 mM; Ultrasonic)
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SMILESO=C(NCC(=O)NCC(=O)NCCOCCOCCOCCOCCNC(=O)CCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1)CN
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.?
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