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Gimeracil
CAS No. 103766-25-2
Gimeracil( Gimestat )
Catalog No. M10190 CAS No. 103766-25-2
An inhibitor of dihydropyrimidine dehydrogenase, degrades pyrimidine including 5-fluorouracil in the blood.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 46 | In Stock |
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| 50MG | 61 | In Stock |
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| 100MG | 81 | In Stock |
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| 200MG | 99 | In Stock |
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| 500MG | 118 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGimeracil
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NoteResearch use only, not for human use.
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Brief DescriptionAn inhibitor of dihydropyrimidine dehydrogenase, degrades pyrimidine including 5-fluorouracil in the blood.
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DescriptionAn inhibitor of dihydropyrimidine dehydrogenase, degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination. Chemotherapeutic Agents Approved(In Vitro):Gimeracil reduces the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1.Gimeracil may enhance the efficacy of radiotherapy through the suppression of HR-mediated DNA repair pathways.Gimeracil pretreatment significantly restrains the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2. (In Vivo):Gimeracil (2.5-25 mg/kg, orally) may inhibit the rapid repair of X-ray-induced DNA damage in tumors.
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In Vitro——
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In VivoAnimal Model:Nude mice (Lu-99, LC-11, KB/C3 and PAN-4 tumors were xenografted).Dosage:2.5-25 mg/kg.Administration:Orally.Result:Exhibited anti-tumor activity.
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SynonymsGimestat
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PathwayOthers
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TargetOther Targets
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RecptorDHPS
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Research AreaCancer
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IndicationChemotherapeutic
Chemical Information
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CAS Number103766-25-2
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Formula Weight145.5438
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Molecular FormulaC5H4ClNO2
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Purity>98% (HPLC)
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SolubilityDMSO: 29 mg/mL
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SMILESO=C1C=C(O)NC=C1Cl
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Chemical Name2(1H)-Pyridinone, 5-chloro-4-hydroxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Adenosine-5'-diphosp...
Adenosine 5'-diphosphate sodium salt is an adenine nucleotide that is phosphorylated into ATP by ATPase. This phosphorylation is a key part of cellular homeostatis as it allows for energy storage and is involved in nucleic acid metabolism. ADP affects platelet activation through its interaction with ADP receptors P2Y1 P2Y12 and P2X1.
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Xenopsin 2TFA(51827-...
Xenopsin(2TFA) is a neurotensin-like octapeptide?previously isolated from amphibian skin.The octapeptide xenopsin, previously isolated from amphibian skin, stimulates exocrine pancreatic secretion of bicarbonate and protein in conscious dogs and increases the volume of secretion.
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Lupeol palmitate
Lupeol palmitate is a naturally occurring compound that can be extracted from Ligularia songarica and has antiulcer activity and gastrointestinal protection.
