Genistin( Genistein glucoside | CS-4240 | NSC5112 | NSC-5112 | Genistin )

Catalog No. M18741 CAS No. 529-59-9

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Product Name

Genistin
Note

Research use only, not for human use.
Brief Description

Genistin, a natural product, is commonly found in soy and soy products.
Description

Genistin is a selective estrogen receptor modulator (SERM) found in soy. It is the less active glycoside analog of genistein. It acts as a phytoestrogen, induces cell cycle arrest and apoptosis in ovarian cancer cells, improves bone density and strength, and decreases myosin light chain kinase levels.
In Vitro

Genistin causes negative regulation of ERα. Genistin also effectively down-modulates ER nuclear translocation as well DNA binding activity in breast cancer cells. Moreover, GS effectively induced apoptosis and suppressed levels of oncogenic markers in MCF-7 cells.
In Vivo

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Synonyms

Genistein glucoside | CS-4240 | NSC5112 | NSC-5112 | Genistin
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

529-59-9
Formula Weight

432.37
Molecular Formula

C21H20O10
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 43 mg/mL; 99.45 mM
SMILES

c1cc(ccc1c1coc2cc(cc(c2c1=O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
Chemical Name

5-hydroxy-3-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

1. Xiong YJ, et al. Arch Pharm Res. 2013 Mar;36(3):345-52.

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