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Genistein

CAS No. 446-72-0

Genistein ( CI-75610; NSC 36586 )

Catalog No. M14528 CAS No. 446-72-0

Genistein(NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Genistein
  • Note
    Research use only, not for human use.
  • Brief Description
    Genistein(NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
  • Description
    Genistein(NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
  • Synonyms
    CI-75610; NSC 36586
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    446-72-0
  • Formula Weight
    270.24
  • Molecular Formula
    C15H10O5
  • Purity
    >98%(HPLC)
  • Solubility
    Ethanol: 2 mg/mL (7.4 mM); DMSO: 54 mg/mL (199.82 mM)
  • SMILES
    O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=CC(O)=C13
  • Chemical Name
    5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Akiyama T, et al. J Biol Chem, 1987, 262(12), 5592-5595.
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