Ganaplacide
CAS No. 1261113-96-5
Ganaplacide ( KAF156;GNF-156 )
Catalog No. M11081 CAS No. 1261113-96-5
Ganaplacide (KAF156, GNF-156)is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 1233 | Get Quote |
|
50MG | 2502 | Get Quote |
|
100MG | 3330 | Get Quote |
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200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameGanaplacide
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NoteResearch use only, not for human use.
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Brief DescriptionGanaplacide (KAF156, GNF-156)is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
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DescriptionGanaplacide (KAF156, GNF-156)is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains; demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively; KAF156 is completely protective as a single oral dose of 10 mg/kg in sporozoite challenge mouse model; shows the potential to treat, prevent, and block the transmission of malaria.Parasite Infection Phase 2 Clinical
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SynonymsKAF156;GNF-156
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorParasite
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Research AreaInfection
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IndicationParasite Infection
Chemical Information
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CAS Number1261113-96-5
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Formula Weight411.46
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Molecular FormulaC22H23F2N5O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(C)C2=NC(C3=CC=C(F)C=C3)=C(NC4=CC=C(F)C=C4)N2CCN1C(CN)=O
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Chemical Name2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kuhen KL, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7.
2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43.
3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.
4. White NJ, et al. N Engl J Med. 2016 Sep 22;375(12):1152-60.
2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43.
3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.
4. White NJ, et al. N Engl J Med. 2016 Sep 22;375(12):1152-60.
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