
Gamabufotalin
CAS No. 465-11-2
Gamabufotalin( —— )
Catalog No. M18569 CAS No. 465-11-2
Gamabufotalin, a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 227 | In Stock |
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10MG | 397 | In Stock |
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25MG | 651 | In Stock |
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50MG | 888 | In Stock |
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100MG | Get Quote | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameGamabufotalin
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NoteResearch use only, not for human use.
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Brief DescriptionGamabufotalin, a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
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DescriptionGamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
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In VitroApoptosis Analysis Cell Line:A549 cells Concentration:0-100 nM Incubation Time:12-48 h Result:Increase the expression levels of the cleaved caspase-3, caspase-9 and PARP.Induced the release of cyt c from mitochondria to cytosol.Immunofluorescence Cell Line:A549 cells Concentration:0-100 nM Incubation Time:12-48 h Result:Inhibited translocation of the NF-κB p65/p50 proteins from cell cytoplasm to nucleus, and induced p300 into the cytoplasm.
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In VivoAnimal Model:A549-xenografts miceDosage:5 and 20 mg/kg/day Administration:i.p., for 17 days Result:Reduced tumor volume and the tumor weights.Decreased COX-2 and p-p65 level in tumors.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorCOX-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number465-11-2
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Formula Weight402.53
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Molecular FormulaC24H34O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (124.22 mM)
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SMILESCC12CCC(CC1CCC3C2C(CC4(C3(CCC4C5=COC(=O)C=C5)O)C)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog



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