Gamabufotalin

CAS No. 465-11-2

Gamabufotalin( —— )

Catalog No. M18569 CAS No. 465-11-2

Gamabufotalin, a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 227 In Stock
10MG 397 In Stock
25MG 651 In Stock
50MG 888 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Gamabufotalin
  • Note
    Research use only, not for human use.
  • Brief Description
    Gamabufotalin, a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
  • Description
    Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
  • In Vitro
    Apoptosis Analysis Cell Line:A549 cells Concentration:0-100 nM Incubation Time:12-48 h Result:Increase the expression levels of the cleaved caspase-3, caspase-9 and PARP.Induced the release of cyt c from mitochondria to cytosol.Immunofluorescence Cell Line:A549 cells Concentration:0-100 nM Incubation Time:12-48 h Result:Inhibited translocation of the NF-κB p65/p50 proteins from cell cytoplasm to nucleus, and induced p300 into the cytoplasm.
  • In Vivo
    Animal Model:A549-xenografts miceDosage:5 and 20 mg/kg/day Administration:i.p., for 17 days Result:Reduced tumor volume and the tumor weights.Decreased COX-2 and p-p65 level in tumors.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    COX-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    465-11-2
  • Formula Weight
    402.53
  • Molecular Formula
    C24H34O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (124.22 mM)
  • SMILES
    CC12CCC(CC1CCC3C2C(CC4(C3(CCC4C5=COC(=O)C=C5)O)C)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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