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Gallopamil

CAS No. 16662-47-8

Gallopamil( Methoxyverapamil )

Catalog No. M26223 CAS No. 16662-47-8

Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gallopamil
  • Note
    Research use only, not for human use.
  • Brief Description
    Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM.
  • Description
    Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.(In Vivo):Gallopamil(5 min) significantly reduces systolic and diastolic blood pressure measured without markedly influencing heart rate. Gallopamil (0.2 mg/kg;i.v.) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF).
  • In Vitro
    ——
  • In Vivo
    Gallopamil (Methoxyverapamil; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate. Animal Model:Male Wistar rats weighing 290-370 g Dosage:0.2 mg/kg Administration:i.v.; 5 minResult:Markedly reduced VT and totally prevented VF.
  • Synonyms
    Methoxyverapamil
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    16662-47-8
  • Formula Weight
    484.637
  • Molecular Formula
    C28H40N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (206.34 mM)
  • SMILES
    COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bolyard K, Gresens SE, Ricko AN, Sivey JD, Salice CJ. Assessing the toxicity of the "inert" safener benoxacor toward Chironomus riparius:Effects of agrochemical mixtures. Environ Toxicol Chem. 2017 Oct;36(10):2660-2670.
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