Galangin

CAS No. 548-83-4

Galangin( Galangin | Norizalpinin )

Catalog No. M18786 CAS No. 548-83-4

Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 27 In Stock
10MG 42 In Stock
25MG 69 In Stock
50MG 111 In Stock
100MG 195 In Stock
500MG 489 In Stock
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Biological Information

  • Product Name
    Galangin
  • Note
    Research use only, not for human use.
  • Brief Description
    Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
  • Description
    Galangin inhibits Ca2+ entry into TRPC5 expressing cells and also induces autophagy.(In Vitro):Galangin (Norizalpinin) inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Galangin | Norizalpinin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ERK| NF-κB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    548-83-4
  • Formula Weight
    270.2
  • Molecular Formula
    C15H10O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 36 mg/mL; 133.21 mM
  • SMILES
    c1ccc(cc1)c1c(c(=O)c2c(cc(cc2o1)O)O)O
  • Chemical Name
    3,5,7-Trihydroxy-2-phenyl-4-benzopyrone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang Y, et al. Toxicology. 2014 Dec 4;326:9-17.
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