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GW0742

CAS No. 317318-84-6

GW0742 ( GW0742; GW-0742; GW 0742; GW0742X )

Catalog No. M17477 CAS No. 317318-84-6

GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GW0742
  • Note
    Research use only, not for human use.
  • Brief Description
    GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).
  • Description
    GW0742, also known as GW610742 and GW0742X is a PPARδ/β agonist. GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons. GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. GW0742 has direct protective effects on right heart hypertrophy.GW0742 may enhance lipid metabolism in heart both in vivo and in vitro.
  • Synonyms
    GW0742; GW-0742; GW 0742; GW0742X
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PPARδ;PPARα;PPARγ
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    317318-84-6
  • Formula Weight
    471.49
  • Molecular Formula
    C21H17F4NO3S2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 34 mg/mL; 72.11 mM
  • SMILES
    Cc1c(CSc2ccc(OCC(=O)O)c(C)c2)sc(n1)c1ccc(c(F)c1)C(F)(F)F
  • Chemical Name
    [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Galuppo M, et al. GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1033-46.
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