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GUT-70
CAS No. 161633-75-6
GUT-70( GUT70 )
Catalog No. M12357 CAS No. 161633-75-6
GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGUT-70
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NoteResearch use only, not for human use.
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Brief DescriptionGUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation.
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DescriptionGUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis; shows binding affinity to heat-shock protein 90 (Hsp90) and ubiquitin-dependent proteasomal degradation of Hsp90 client proteins, including cyclin D1, Raf-1, Akt, and mt-p53; also inhibits HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB.
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In Vitro——
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In Vivo——
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SynonymsGUT70
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number161633-75-6
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Formula Weight382.456
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Molecular FormulaC23H26O5
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2H,8H-Benzo[1,2-b:3,4-b']dipyran-8-one, 5-methoxy-2,2-dimethyl-6-(2-methyl-1-oxo-2-butenyl)-10-propyl-, (E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kimura S, et al. Int J Cancer. 2005 Jan 1;113(1):158-65.
2. Jin L, et al. Br J Cancer. 2011 Jan 4;104(1):91-100.
3. Kudo E, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):606-9.
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