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GUT-70

CAS No. 161633-75-6

GUT-70 ( GUT70 )

Catalog No. M12357 CAS No. 161633-75-6

GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GUT-70
  • Note
    Research use only, not for human use.
  • Brief Description
    GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation.
  • Description
    GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis; shows binding affinity to heat-shock protein 90 (Hsp90) and ubiquitin-dependent proteasomal degradation of Hsp90 client proteins, including cyclin D1, Raf-1, Akt, and mt-p53; also inhibits HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB.
  • Synonyms
    GUT70
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    161633-75-6
  • Formula Weight
    382.46
  • Molecular Formula
    C23H26O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2H,8H-Benzo[1,2-b:3,4-b']dipyran-8-one, 5-methoxy-2,2-dimethyl-6-(2-methyl-1-oxo-2-butenyl)-10-propyl-, (E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kimura S, et al. Int J Cancer. 2005 Jan 1;113(1):158-65.
2. Jin L, et al. Br J Cancer. 2011 Jan 4;104(1):91-100.
3. Kudo E, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):606-9.
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