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GSK9027
CAS No. 1229096-88-1
GSK9027( —— )
Catalog No. M33859 CAS No. 1229096-88-1
GSK9027 (GR agonist 23a) is a nonsteroidal glucocorticoid receptor (GR) agonist.GSK9027 is a partial agonist on the 2×GRE reporter gene compared to dexamethasone and is less active than dexamethasone activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 82 | Get Quote |
|
| 5MG | 122 | Get Quote |
|
| 10MG | 202 | Get Quote |
|
| 25MG | 411 | Get Quote |
|
| 50MG | 594 | Get Quote |
|
| 100MG | 799 | Get Quote |
|
| 500MG | 1611 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK9027
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NoteResearch use only, not for human use.
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Brief DescriptionGSK9027 (GR agonist 23a) is a nonsteroidal glucocorticoid receptor (GR) agonist.GSK9027 is a partial agonist on the 2×GRE reporter gene compared to dexamethasone and is less active than dexamethasone activity.
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DescriptionGSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone.
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In VitroGSK9027 demonstrates reduced 2×GRE reporter activation and is partial agonists.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGlucocorticoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1229096-88-1
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Formula Weight525.52
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Molecular FormulaC27H19F4N3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (475.72 mM; Ultrasonic )
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SMILESFC1=CC=C(N2C=3C(=CC(=CC3)C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=N2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rider CF, et al. Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands. PLoS ONE. 2015; 10(1): e0116773.
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