GSK8814
CAS No. 1997369-78-4
GSK8814 ( GSK 8814;GSK-8814 )
Catalog No. M13118 CAS No. 1997369-78-4
GSK8814 is a potent, selective inhibitor of ATAD2/2B bromodomain binding constant pKd of 8.1 in ITC assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 344 | Get Quote |
|
50MG | 1503 | Get Quote |
|
100MG | 2277 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK8814
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NoteResearch use only, not for human use.
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Brief DescriptionGSK8814 is a potent, selective inhibitor of ATAD2/2B bromodomain binding constant pKd of 8.1 in ITC assays.
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DescriptionGSK8814 is a potent, selective inhibitor of ATAD2/2B bromodomain binding constant pKd of 8.1 in ITC assays; displaces acetylated H4 peptide from the ATAD2 bromodomain with pIC50 of 7.3 and is also active in BROMOscan with pKi of 8.9, displays >100 fold selective over all other bromodomains and >1,000 fold selective over BRD4; shows cellular target engagement with an EC50 of 2 μM in a NanoBRET assay evaluating the interaction of the NanoLuc-ATAD2 bromodomain with histone H3.3-HaloTag.
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SynonymsGSK 8814;GSK-8814
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number1997369-78-4
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Formula Weight527.62
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Molecular FormulaC28H35F2N5O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C(N1)=O)=CC2=C1C(N[C@H]3[C@H](OCC4CCC(F)(F)CC4)CNC[C@@H]3OC)=NC=C2C5=CN=CC(C)=C5
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Chemical Name8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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