GSK693( GSK-693 | GSK 693 )

Catalog No. M11537 CAS No. 1372891-37-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK693
Note

Research use only, not for human use.
Brief Description

GSK693 (GSK-693) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM.
Description

GSK693 (GSK-693) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM, shows equally potent activity against M. tuberculosis H37Rv both intra and extracellularly (MIC=0.2 uM); exhibits activities against multidrug (MDR) and extensively (XDR) drug-resistant clinical isolates as well as in TB murine models when orally dosed.
In Vitro

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In Vivo

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Synonyms

GSK-693 | GSK 693
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

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Indication

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CAS Number

1372891-37-6
Formula Weight

419.54
Molecular Formula

C16H17N7OS3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(S)-1-(4-methylthiazol-2-yl)-1-(5-((1-((2-methylthiazol-4-yl)methyl)-1H-pyrazol-3-yl)amino)-1,3,4-thiadiazol-2-yl)ethanol

1. Martínez-Hoyos M, et al. EBioMedicine. 2016 Jun;8:291-301.

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