GSK429286A ( GSK429286A; GSK 429286A )

Catalog No. M17626 CAS No. 864082-47-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK429286A
Note

Research use only, not for human use.
Brief Description

GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
Description

GSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.
Synonyms

GSK429286A; GSK 429286A
Pathway

Others
Target

Other Targets
Recptor

ROCK1; ROCK2
Research Area

Cancer
Indication

——

CAS Number

864082-47-3
Formula Weight

432.37
Molecular Formula

C21H16F4N4O2
Purity

98%
Solubility

DMSO : ≥ 51 mg/mL; 117.95 mM
SMILES

CC1=C(C(CC(=O)N1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1c(cc2c(c1)cn[nH]2)F
Chemical Name

N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide

1. Goodman KB, et al. J Med Chem, 2007, 50(1), 6-9.

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