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GSK429286A
CAS No. 864082-47-3
GSK429286A ( GSK429286A; GSK 429286A )
Catalog No. M17626 CAS No. 864082-47-3
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 25MG | 125 | In Stock |
|
| 50MG | 194 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK429286A
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NoteResearch use only, not for human use.
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Brief DescriptionGSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
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DescriptionGSK429286A is a selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.
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SynonymsGSK429286A; GSK 429286A
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PathwayOthers
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TargetOther Targets
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RecptorROCK1; ROCK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number864082-47-3
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Formula Weight432.37
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Molecular FormulaC21H16F4N4O2
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Purity98%
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SolubilityDMSO : ≥ 51 mg/mL; 117.95 mM
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SMILESCC1=C(C(CC(=O)N1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1c(cc2c(c1)cn[nH]2)F
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Chemical NameN-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Goodman KB, et al. J Med Chem, 2007, 50(1), 6-9.
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