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GSK4112
CAS No. 1216744-19-2
GSK4112 ( SR6452;GSK-4112;GSK 4112;SR-6452;SR 6452 )
Catalog No. M10812 CAS No. 1216744-19-2
A potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 69 | In Stock |
|
| 25MG | 147 | In Stock |
|
| 50MG | 266 | In Stock |
|
| 100MG | 478 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK4112
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay.
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DescriptionA potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assay; mediates the repression of Rev-erbα target gene bmal1 in liver cells, and inhibits and shifts the phase of gluconeogenesis in primary mouse hepatocytes.
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SynonymsSR6452;GSK-4112;GSK 4112;SR-6452;SR 6452
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PathwayAutophagy
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TargetAutophagy
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RecptorRev-ErbBα
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1216744-19-2
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Formula Weight396.89
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Molecular FormulaC18H21ClN2O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(OC(C)(C)C)CN(CC1=CC=C(Cl)C=C1)CC2=CC=C([N+]([O-])=O)S2
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Chemical NameGlycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Grant D, et al. ACS Chem Biol. 2010 Oct 15;5(10):925-32.
2. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2;11(11):1987-1997.
2. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2;11(11):1987-1997.
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