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GSK3004774

CAS No. 2138814-32-9

GSK3004774( GSK 3004774 | GSK-3004774 )

Catalog No. M13412 CAS No. 2138814-32-9

GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GSK3004774
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3.
  • Description
    GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3; demonstrates low permeability and low portal drug concentrations and high luminal stability and high fecal drug recovery in vivo DMPK experiments.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK 3004774 | GSK-3004774
  • Pathway
    GPCR/G Protein
  • Target
    CaSR
  • Recptor
    CaSR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2138814-32-9
  • Formula Weight
    528.697
  • Molecular Formula
    C32H40N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (189.15 mM)
  • SMILES
    CC(C1=CC=CC2=CC=CC=C21)NC3CCN(C3)C4=CC=C(C=C4)C(=O)NCCCN5CCC(CC5)C(=O)O
  • Chemical Name
    1-(3-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)benzamido)propyl)piperidine-4-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.? Sparks?SM,?et?al.?Bioorg?Med?Chem?Lett.?2017?Oct?15;27(20):4673-4677.
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