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GSK3-IN-3

CAS No. 331963-27-0

GSK3-IN-3( —— )

Catalog No. M36514 CAS No. 331963-27-0

GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK3-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.
  • Description
    GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA.
  • In Vitro
    ImmunofluorescenceCell Line:Parkin-expressing U2OS-iMLS cells Concentration:1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM, and 25 μM; Incubation Time:24 hour sResult:Induced a mitochondrial morphology change from a filament-shaped network to a more round-shaped network.Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:0.5 μM, 1 μM, 3 μM, 5 μM, and 10 μM Incubation Time:16 hours; with 35 μM 6-OHDA Result:Inhibited cell growth with an IC50 value of 2.57 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    Mitophagy | GSK-3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    331963-27-0
  • Formula Weight
    429.55
  • Molecular Formula
    C24H35N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 4.17 mg/mL (9.71 mM; Ultrasonic (<60°C)
  • SMILES
    C(C)N1C=2C(C(O)=C(C(NNC(CCCCCCCCCCC)=O)=O)C1=O)=CC=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Maestro I, et al. Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease. ACS Chem Neurosci. 2021 Dec 15;12(24):4512-4523. ?
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