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GSK256073

CAS No. 862892-90-8

GSK256073( —— )

Catalog No. M24859 CAS No. 862892-90-8

GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK256073
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist.
  • Description
    GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis.
  • In Vitro
    ——
  • In Vivo
    Animal Model:SD ratDosage:1, 30 and 100 mg/kg Administration:Oral adminstration Result:Inhibited NEFA expression as a dose-dependent manner. Animal Model:Guinea pigs Dosage:10 mg/kg Administration: Intravenous?injection Result:Had the antilipolytic and flushing effects as a HCA2 agonist.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR109A|HCA2 (hydroxy-carboxylic acid receptor 2)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    862892-90-8
  • Formula Weight
    256.69
  • Molecular Formula
    C10H13ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:16.67 mg/mL?(64.94 mM;?Need ultrasonic)
  • SMILES
    CCCCCN1C2=C(C(=O)NC1=O)NC(=N2)Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dobbins RL, et al. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.Diabetes Obes Metab.?2013 Nov;15(11):1013-21.
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