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GSK2190915
CAS No. 936350-00-4
GSK2190915( AM-803 | Fiboflapon | GSK-2190915 )
Catalog No. M16702 CAS No. 936350-00-4
A potent, selective FLAP inhibitor with binding IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 743 | Get Quote |
|
| 100MG | 1116 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK2190915
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective FLAP inhibitor with binding IC50 of 2.6 nM.
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DescriptionA potent, selective FLAP inhibitor with binding IC50 of 2.6 nM; inhibits LTB4 synthesis following ionophore challenge in human whole blood with IC50 of 76 nM (5 h incubation); shows good selectivity over CYP3A4, 2C9, and 2D6; exhibits excellent preclinical toxicology, pharmacokinetics and oral bioactivity.Asthma Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAM-803 | Fiboflapon | GSK-2190915
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PathwayImmunology/Inflammation
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TargetFLAP
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RecptorFLAP
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number936350-00-4
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Formula Weight637.8307
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Molecular FormulaC38H43N3O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCCOC1=NC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OCC5=NC=C(C=C5)C)C(=C3CC(C)(C)C(=O)O)SC(C)(C)C
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Chemical Name1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stock NS, et al. J Med Chem. 2011 Dec 8;54(23):8013-29.
2. Lorrain DS, et al. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8.
3. Kent SE, et al. Clin Exp Allergy. 2013 Feb;43(2):177-86.
molnova catalog
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